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15 Best Serums to Treat Acne, According to a Dermatologist

There's a serum for every kind of breakout you could possibly imagine.

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There's no telling when a breakout will strike or how severe it will be. For some besties, all it takes is a spot treatment or a pimple patch to zap a zit before it breaks through the skin and leaves behind pesky dark marks. Others need stronger pore-clearing cleansers and masks to remove the buildup, like blackheads and whiteheads that lead to breakouts. Acne serums are a skincare essential that help combat active blemishes and prevent future breakouts. According to board-certified dermatologist Dr. Shari Sperling, they also help reduce leftover marks from hyperpigmentation and scarring. The best serums for acne-prone skin work so well because they "generally have higher concentrations of active ingredients," she explains to Seventeen.

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When it comes to acne-prone skin, Dr. Sperling recommends serums that are formulated to target the different concerns you're experiencing. Acne scarring and hyperpigmentation often appear after breakouts. The New Jersey-based derm suggests retinol-enriched acne serums to remove the buildup that leads to acne and stimulate collagen and elastin production to keep skin firm and reduce the appearance of pesky marks. If you're experiencing dryness and peeling, serums with hydrating niacinamide decrease oil production and reduce inflammation and redness, she says. For active breakouts, Dr. Sperling recommends serums laced with exfoliating benzoyl peroxide to clear oil and dead skin cells out of pores to prevent future breakouts and increase skin cell turnover, which helps with hyperpigmentation and scarring.

Since acne serums are packed with a higher concentration of breakout-fighting ingredients, Dr. Sperling warns of possible irritation depending on how sensitive your skin is. Instead of applying a new serum to your breakout as soon as it appears, start by spot testing with a small amount of product to the inner upper arm to see if you have a reaction. "Always review the ingredients" and "make sure the product is non-comedogenic" to prevent clogged pores, she warns.

No matter if you're experiencing active breakouts or want to get rid of leftover marks from acne scars, there are serums to help improve your skin's condition. Read ahead for the best serums for acne-prone skin, according to experts.

1
Best for Blackheads

The INKEY List Beta Hydroxy Acid (BHA) Blemish + Blackhead Serum

Beta Hydroxy Acid (BHA) Blemish + Blackhead Serum
$13 at Sephora$23 at Walmart
Pros
  • Doesn't dry skin out
  • Clears out blackheads
Cons
  • Customer reviews note small bottle size

Blackheads can pop up anywhere from your face to your nose and ears. Dr. Sperling recommends this BHA serum because it's enriched with salicylic acid and zinc to decongest clogged pores and control oil production.

Key ingredients: Salicylic acid, zinc compound 1%, hyaluronic acid

Skin type: Combination, oily, normal

Customer review: "This serum did clear my blackheads and it is great because it doesn't peel off your face like other serums I wish it came in a bigger size."

2
Best for Dry Skin

BioRepublic SkinCare Super Collagen + Detox Glacial Algae Serum

Super Collagen + Detox Glacial Algae Serum
Pros
  • Leaves skin glowing and soft
Cons
  • Small size

There's nothing like the pain from a pimple that's trying to break through the skin. This lightweight serum removes toxins from the skin and helps reduce inflammation.

Key ingredients: Glacial algae, collagen

Skin type: Dry, sensitive

Customer review: "Never had my skin so glowy and amazing.. always loved algae but never knew I needed it for my face. Can't go without now."

3

Drunk Elephant T.L.C. Framboos™ Glycolic Resurfacing Night Serum

T.L.C. Framboos™ Glycolic Resurfacing Night Serum
Now 33% Off
Pros
  • Hydrating
  • Softens skin
Cons
  • High price point

Drunk Elephant T.L.C. Framboos Glycolic Resurfacing Night Serum is an exfoliating skincare essential that's laced with gunk-clearing glycolic, lactic, tartaric, citric, and salicylic acids to gently exfoliate and reveal smoother, more radiant skin, Dr. Sperling says.

Key ingredients: Glycolic acid, lactic acid, tartaric acid, citric acid, salicylic acid

Skin type: Normal, dry, oily, combination

Customer review: "This product has a great feel to it and last for a very long time I had the mini version and used two pumps daily and it lasted me 3 months this version has definitely lasted me a lot longer its really also hydrating."

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4
Best for Active Breakouts

La Roche-Posay Effaclar Duo Acne Spot Treatment

Effaclar Duo Acne Spot Treatment
Pros
  • Can be used as a spot treatment or all over the face
  • Doesn't dry out the skin
Cons
  • Customer reviews note irritation in sensitive skin types

This spot treatment reduces blemishes and clears blackheads and whiteheads. It's packed with a non-drying, oil-free formula that absorbs quickly into the skin. Benzoyl peroxide is the key ingredient that helps this treatment reduce acne-causing bacteria, Dr. Sperling says.

Key ingredients: Benzoyl peroxide

Skin type: Combination, oily

Customer review: "I get really bad hormonal acne and this product helped a lot with it. For me personally it takes about a couple days for my acne to heal using this product."

5
Best for Normal to Combination Skin

The Ordinary Retinol 0.5% in Squalane

Retinol 0.5% in Squalane
Pros
Cons

Get ready to tackle your acne and skin's texture with The Ordinary Retinol 0.5% in Squalane serum. Dr. Sperling raves over this serum because it "suppresses oil production to treat acne, and squalene, which increases hydration." Since there's active retinol in this serum, be sure not to use it with vitamin C or Copper Peptides to prevent irritation.

Key ingredients: Retinol, squalane

Skin type: Normal, combination

Customer review: "I have been using this for about a month. I apply at night after cleansing, and I simply use toner and a thick PM moisturizer that doesn't have any clashing ingredients. It feels slightly oily when you are applying it. I have definitely seen improvements with my skin, and I luckily have not had any adverse reactions. Just make sure you educate yourself and read the label, and I would totally recommend it!"

6
Best Spot Treatment

Malin + Goetz Acne Treatment Nighttime

Acne Treatment Nighttime
Pros
  • Reduces redness and inflammation
  • Dries out active breakouts quickly
Cons
  • Customer reviews note strong smell

Pimples always strike at an inconvenient time. If you're in a rush and have an active breakout, this salicylic acid and active sulfur-enriched treatment dries out inflammation and reduces redness overnight.

Key ingredients: Salicylic acid, 10% active sulfur

Skin type: Normal, oily, combination, dry

Customer review: "It works wonders! Better than anything else I’ve ever tried. However it does smell really strong."

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7
Best to Wear with Makeup

Glow Recipe Strawberry Smooth BHA + AHA Salicylic Acid Serum

Strawberry Smooth BHA + AHA Salicylic Acid Serum
Pros
  • Nourishes skin
  • Doesn't cause purging
Cons
  • Customer reviews note gummy texture

If you're looking for a good serum to wear with your makeup, grab this lightweight option from Glow Recipe. Hyaluronic acid nourishes skin while clarity acid complex 10% exfoliates dead skin cells and reduces the appearance of bumps.

Key ingredients: Clarity acid complex 10%, strawberry extract, hyaluronic acid

Skin type: Normal, dry, combination, oily

Customer review: "I have suffered from cystic acne for years. I have used over the counter and prescription medications...and nothing worked. Strawberry Smooth by Glow Recipe did the job!!! I no longer have cystic acne. When I do get a rare small pimple I spot treat it and it's gone in 2 day. I wish I this product years ago."

8
Best Vegan Serum

VERSED Just Breathe Clarifying Serum

Just Breathe Clarifying Serum
Pros
  • Clears out pores without stripping
  • Doesn't irritate most skin types
Cons
  • Customer reviews note light texture

Apply two to three drops into clean, moist-but-almost-dry skin to remove gunk and combat excess oil production. Willow bark extract, niacinamide, and a zinc blend soothe inflammation, clear pores, and reduce redness.

Key ingredients: Niacinamide, willow bark extract, zinc

Skin type: Oily, normal, combination

Customer review: "Very good product it helps a lot with oiliness and clogged pores."

9

Urban Skin Rx Clear Complexion Acne Serum + Spot Treatment

Clear Complexion Acne Serum + Spot Treatment
Pros
  • Fast-acting
  • Works on hormonal breakouts
Cons
  • Customer reviews note stinging sensation on open breakouts and fully-dried skin

For some besties, hormonal breakouts surface like clockwork signaling that their cycle is otw. This fast-drying gel reduces inflammation and soothes the pain from large breakouts.

Key ingredients: 5% Benzoyl peroxide, 5% glycolic acid

Skin type: Oily, combination

Customer review:"Brings pimples to a head quickly. Shrinks large painful ones overnight. This stuff has really helped within a day of using it. I'm purchasing it from using a sample. I haven't tried to use as a preventative only a spot treatment."

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10
Best for On The Go Treatment

HERO COSMETICS Lightning Wand

Lightning Wand

There's no telling when you'll get a zip, so this lightweight pen is perfect for when you're on the go. Throw one in your backpack to zap breakouts that pop up when you're headed across campus or in your makeup bag for when you're traveling with your besties during your next break from school.

Key ingredients: Glycolic acid, niacinamide, vitamin c, tranexamic acid

Skin type: Normal, oily, combination

Customer review: "I stumbled on this while searching for ways to reduce appearances of acne(after it's been popped) and dark spots. It works super well, I had a bad patch of acne and I applied it twice a day and by the weekend, the spots had almost gone! I'd suggest this for anyone who is looking to lighten their acne after being picked."

11

Sunday Riley U.F.O. Ultra-Clarifying BHA Salicylic Acid and Tea Tree Acne Treatment Face Oil

U.F.O. Ultra-Clarifying BHA Salicylic Acid and Tea Tree Acne Treatment Face Oil
Pros
  • Treats active breakouts without drying
Cons
  • Customer reviews note expensive price

Besties, have you heard about tea tree oil? It's laced with antibacterial properties to help reduce inflammation. This Sunday Riley serum combines tea tree oil with exfoliating salicylic acid to buff away dead skin cells and decongest clogged pores.

Key ingredients: Salicylic acid, tea tree oil

Skin type: Normal, oily, combination

Customer review: "Seems a little expensive but a little goes a long way and your skin will thank you !!"

12
Best for Cystic Acne

Renee Rouleau Post-Breakout Fading Gel

Post-Breakout Fading Gel
Pros
  • Lightens hyperpigmentation
  • Fast-absorbing and lightweight
Cons
  • Customer reviews note strong fragrance

No matter if your cystic acne leaves behind red marks or dark scars, this fast-acting gel helps brighten and reduces inflammation from leftover breakouts.

Key ingredients: Green tea extract, lactic acid, glycolic acid, sea whip extract

Skin type: Normal, oily, dry, combination

Customer review: "I love this product! It is really helping to fade some off my old scars, especially when used together with the other RR product range for my skin type."

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13

Naturium Azelaic Topical Acid 10%, Brightening Face & Skin Care Treatment

Azelaic Topical Acid 10%, Brightening Face & Skin Care Treatment

You may know Naturium for its viral body washes, but this serum is in a league of its own. Along with gently slough away dead skin cells, this hydrating serum reduces discoloration and hydrates skin.

Key ingredients: Niacinamide, azelaic acid, vitamin C

Skin type: Normal, oily, combination, dry

Customer review:"Fave skincare product bc its the only one ive actually seen make a difference, i know it works for my skin. its a staple in my skincare routine. i dont love the smell but ive tried other products with the same ingredients and they did not work.i have rosacea and this product really helps the appearance and health of my skin!"

14
Best for Sensitve Skin

Vichy Mineral 89 Niacinamide Serum

Mineral 89 Niacinamide Serum
Pros
  • Nourishes skin
  • Improves skin's texture
Cons
  • Customer reviews note concerns over applicator tool

This easily absorbed serum hydrates, brightens, and minimizes the appearance of pores.

Key ingredients: Niacinamide

Skin type: Sensitive

Customer review: "I’ve used both vitamin c and niacinamide for my dark spots and this has been the best I’ve used yet. Noticeable difference in my sun spots and my aesthetician even commented on how nice my skin texture was after using for awhile."

15
Best for Textured Skin

CeraVe Retinol Serum for Post-Acne Marks and Skin Texture

Retinol Serum for Post-Acne Marks and Skin Texture
Pros
  • Helps improve acne scars and hyperpigmentation
  • Does not lead to drying
  • Hydrates without leaving skin oily or greasy
Cons
  • Customer reviews note length of time it takes to fully fade acne scars

This one's for the besties that have said farewell to active breakouts but are now experiencing discoloration and uneven skin texture courtesy of old blemishes. Grab this super-affordable drugstore find to help smooth and even your complexion.

Key ingredients: Encapsulated retinol, licorice root extract, niacinamide

Skin type: Normal, dry, oily, sensitive, combination

Customer review: "I use this a few times a week and it really does help with the scars, without over moisturizing your skin. Perfect product and I have been buying it for about a year now!"

Headshot of Jasmine Washington
Jasmine Washington
Assistant Editor

Jasmine Washington is an Assistant Editor at Seventeen, where she covers celebrity news, beauty, lifestyle, and more. For the past decade, she has worked for media outlets, including BET, MadameNoire, VH1, and many others, where she used her voice to tell stories across various verticals. Follow her on Instagram.

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